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Poster

Norma: A Noise Robust Memory-Augmented Framework for Whole Slide Image Classification

Yu Bai · Bo Zhang · Zheng Zhang · Shuo Yan · Zibo Ma · Wu Liu · Xiuzhuang Zhou · Xiangyang Gong · Wendong Wang

Strong blind review: This paper was not made available on public preprint services during the review process Strong Double Blind
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Thu 3 Oct 7:30 a.m. PDT — 9:30 a.m. PDT

Abstract:

In recent years, the Whole Slide Image (WSI) classification task has achieved great advancement due to the success of Multiple Instance Learning (MIL). However, MIL-based methods face two limitations: 1) often select the top-ranking instances of a WSI based on different metrics (e.g., attention score) to train the model due to the large resolution of WSIs, which may lead to missing global information; 2) usually consider all instances within a bag to be unordered, which will cause the local context information to be missing. To address the limitations of MIL-based methods, we formulate the WSI classification task as a long sequence classification problem in a weakly supervised setting. We propose a Noise Robust Memory-augmented (Norma) framework that serializes the WSI into an ordered sequence and caches each segment for future reuse in a sequential manner. By applying such paradiam, global and local context information of a WSI can be obtained during training. Furthermore, Normal adopts a Cyclic Training process to eliminate the noise introduced by the WSI-level labe. We obtains state-of-the-art results on CAMELYON-16, TCGA-BRAC and TCGA-LUNG datasets. We will release the code upon acceptance.

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