This work aims to address an advanced keypoint detection problem: how to accurately detect any keypoints in complex real-world scenarios, which involves massive, messy, and open-ended objects as well as their associated keypoints definitions. Current high-performance keypoint detectors often fail to tackle this problem due to their two-stage schemes, under-explored prompt designs, and limited training data. To bridge the gap, we propose the X-Pose, a novel end-to-end framework with multi-modal (i.e., visual, textual or their combinations) prompts to detect multi-object keypoints for any articulated (e.g., human and animal), rigid, and soft objects within a given image. Moreover, we introduce a large-scale dataset called UniKPT, which unifies 13 keypoint detection datasets with 338 keypoints across 1,237 categories over 400K instances. Training with UniKPT, X-Pose effectively aligns text-to-keypoint and image-to-keypoint due to the mutual enhancement of multi-modal prompts based on cross-modality contrastive learning. Our experimental results demonstrate that X-Pose achieves notable improvements of 27.7 AP, 6.44 PCK and 7.0 AP compared to state-of-the-art non-promptable, visual prompt-based, and textual prompt-based methods in each respective fair setting. More importantly, the in-the-wild test demonstrates X-Pose's strong fine-grained keypoint localization and generalization abilities across image styles, object categories, and poses, paving a new path to mutli-object keypoint detection in real applications.