Domain Generalization (DG) focuses on enhancing the generalization of deep learning models trained on multiple source domains to adapt to unseen target domains. This paper explores DG through the lens of bias-variance decomposition, uncovering that test errors in DG predominantly arise from cross-domain bias and variance. Inspired by this insight, we introduce a Representation Enhancement-Stabilization (RES) framework, comprising a Representation Enhancement (RE) module and a Representation Stabilization (RS) module. In RE, a novel set of feature frequency augmentation techniques is used to progressively reduce cross-domain bias during feature extraction. Furthermore, in RS, a novel Mutual Exponential Moving Average (MEMA) strategy is designed to stabilize model optimization for diminishing cross-domain variance during training. Collectively, the whole RES method can significantly enhance model generalization. We evaluate RES on five benchmark datasets and the results show that it outperforms multiple advanced DG methods. Our code will be publicly available.