PSALM is a powerful extension of the Large Multi-modal Model (LMM) to address the segmentation task challenges. To overcome the limitation of the LMM being limited to textual output, PSALM incorporates a mask decoder and a well-designed input schema to handle a variety of segmentation tasks. This schema includes images, task instructions, conditional prompts, and mask tokens, which enable the model to generate and classify segmentation masks effectively. The flexible design of PSALM supports joint training across multiple datasets and tasks, leading to improved performance and task generalization. PSALM achieves superior results on several benchmarks, such as RefCOCO/RefCOCO+/RefCOCOg, COCO Panoptic Segmentation, and COCO-Interactive, and further exhibits zero-shot capabilities on unseen tasks, such as open-vocabulary segmentation, generalized referring expression segmentation and video object segmentation, making a significant step towards a GPT moment in computer vision. Through extensive experiments, PSALM demonstrates its potential to transform the domain of image segmentation, leveraging the robust visual understanding capabilities of LMMs as seen in natural language processing.